Novel Topical Anaesthesia for rapid wound numbing and prolonged analgesia for open wounds
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How can painful wound care be made easier when injectable anaesthesia is impractical and opioids create additional limitations? This Trauma Club session explores a topical spray-and-gel formulation combining lidocaine, bupivacaine, epinephrine and cetrimide.
The speakers discuss first-in-human data from 24 patients with traumatic lacerations, including rapid onset of anaesthesia, prolonged effect and safety monitoring. The conversation then moves into the questions that matter at the bedside: wound size and depth, exposed nerve endings, contaminated wounds, antimicrobial activity, multimodal analgesia, nerve blocks, dressings and potential military use.
The most interesting part is where the evidence meets real-world surgical problems—especially painful debridement and dressing changes, large contaminated wounds and the need to bridge the analgesic gap before definitive care. Several potential applications remain open for further study.
The speakers discuss first-in-human data from 24 patients with traumatic lacerations, including rapid onset of anaesthesia, prolonged effect and safety monitoring. The conversation then moves into the questions that matter at the bedside: wound size and depth, exposed nerve endings, contaminated wounds, antimicrobial activity, multimodal analgesia, nerve blocks, dressings and potential military use.
The most interesting part is where the evidence meets real-world surgical problems—especially painful debridement and dressing changes, large contaminated wounds and the need to bridge the analgesic gap before definitive care. Several potential applications remain open for further study.
EDU-LECTURES
Course
Educational Lectures
01
1:02:13 Now playing
Novel Topical Anaesthesia for rapid wound numbing and prolonged analgesia for open woundsA practical discussion of a topical anaesthetic designed to rapidly numb open wounds while providing prolonged analgesia and antimicrobial activity, with potential applications in trauma and military medicine.
02
1:47:48
Role 1 and Role 2: Scope, Requirements, Challenges and OpportunitiesFrontline experience of organizing Role 1 and Role 2 trauma care when evacuation takes hours, resources are limited, and patient flow can change within minutes. The speakers examine triage, hemorrhage control, blood transfusion, surgical limits, mass-casualty workflows, evacuation, and the decisions that determine whether an intervention helps or only delays definitive care.
03
1:06:11
Debridement and Management of Open Fractures in Combat TraumaA practical lecture on open fractures and combat wounds, centered on meticulous debridement, infection prevention, temporary stabilization, soft-tissue coverage, and real clinical cases.
Novel Topical Anaesthesia for rapid wound numbing and prolonged analgesia for open wounds